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5C forskningsprojekter

The overcoming of tumor antigen heterogeneity in diffuse midline glioma (DMG) with help from next generation CAR T-cell therapy

In this project we want to develop a new type of CAR T-cell therapy, which delivers a number of bi specific antibodies aimed at tumor invasive macrophage/microglia cells in the tumor environment. In doing this we can aim the attack on the tumor cells with several antigens at once and potentially overcome problems with tumor antigen heterogeneity.

Coordinator

Maria Ormhøj, Assistant Professor

Supervisor / Partners

Maria Ormhøj, Assistant Professor, and René Mathiasen, Consultant, Clinical lector and PhD

Where

University of Southern Denmark and Bonkolab

Contact information

Maor@igt.sdu.dk

Visual impairment in children with primary brain tumours

The aim of the study is to investigate the diagnostic and prognostic significance of visual impairment as a symptom and/or clinical finding among paediatric patients diagnosed with brain tumours.

Coordinator

Caroline Sophie Kleis Schmidt, Medical Student, Scholar

Supervisor / Partners

Sarah Linea von Holstein, Consultant, Clinical lector and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology

Where

Bonkolab and Eye Clinic Rigshospitalet-Glostrup

European study of cerebellar mutism syndrome (CMS) in children with posterior fossa tumors

Prospective clinical study that follows children after tumor surgery in the cerebellum, and which examines which children are affected by muteness, balance and coordination difficulties, paralysis and emotional disturbances - cerebellar mutism syndrome.

Coordinator

Aske Foldbjerg Laustsen, Medical Doctor, PhD student

Supervisor / Partners

Marianne Juhler, Consultant and Professor in neurosurgery, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology, René Mathiasen, Consultant, Clinical lector and PhD, Astrid Marie Sehested, Consultant, and Jonathan Kjær Grønbæk, Doctor and PhD

Where

International multicenter study based on Rigshospitalet

Eye symptoms in children with brain cancer

Retrospective study of eye symptoms in children with brain tumours in the time leading up to diagnosis with the aim of earlier diagnosis

Coordinator

Sarah Linea von Holstein, Consultant, Clinical lector and PhD

Supervisor / Partners

René Mathiasen, Consultant, Clinical lector and PhD, Kamilla Nissen, Consultant, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology, Astrid Sehested, Consultant, Peter Toft, Chief Consultantm and Steffen Heegaard, Clinical professor

Where

Eye Clinic Rigshospitalet-Glostrup

The evaluation of the response from different cellular populations targeted drug screening for brain tumors in children to identify new drug combinations

The target with this study is to identify markers for several tumor cell populations primarily for DMG and medulloblastoma, which can be used with flow cytometry to evaluate how both standard treatment and the targeted treatment affect the different tumor cell populations. By discovering drugs that target single cellular populations, do we want to examine combinations of drugs that target several cell populations at the same time. Our hypothesis is that by targeting several tumor cell populations, we can develop more effective treatments, which prevents tumor cells from growing back.

Coordinator

Oneka Perea Ariznabarreta PhD student and Jason Linnebjerg Haw, PhD student

Supervisor / Partners

Krister Wennerberg, Professor and group leader The Wennerberg Group (BRIC), Rene Mathiasen, Consultant, Clinical lector, and Signe Modvig, Doctor, Clinical lector and PhD

Where

The Wennerberg group at BRIC, Tissue Typing laboratory at RH and Bonkolab

"Hjernetegn"

A Danish awareness campaign focusing on reducing time to diagnosis in children and adolescents with brain tumours.

Coordinator

Louise Tram Henriksen, Medical Doctor and PhD

Supervisor / Partners

René Mathiasen, Consultant, Clinical lector and PhD, and Henrik Hasle, Consultant, Clinical lector and PhD

Where

Children and Young People, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University

Contact information

kathrineweile@clin.au.dk

IMPACT-PBT: Intra-operative Management and Prevention through Allied Collaboration for Treatment of Pediatric Brain Tumors

A retrospective study that aims to investigate various intra-operative complications associated with pediatric brain tumor surgery and identifying potential risk factors.

Coordinator

Clara Matilde Holck Wæhrens, Medical Student, Scholar

Supervisor / Partners

René Mathiasen. Consultant, Clinical lecturer and PhD, Martin Krypsin Sørensen, Consultant, Clinical lecturer and PhD, Kirsten Møller, Consultant and Professor, Jon Foss-Skiftesvik, Attending physician and PhD, Jane Skøjt-Rasmussen Consultant, Clinical lecturer and PhD, Astrid Sehested, Consultant and Christine Dahl, Consultant

Where

Bonkolab, Department of Neuroanaesthesiology, and Department of Neurosurgery

Cerebrospinal fluid in children with CNS malignancies

The project investigates with proteo- and glycomics specific properties of the cerebrospinal fluid during oncological conditions of the central nervous system in children and adolescents. The aim of the project is to develop the concept of liquid biopsy in paediatric neuro-oncology.

Coordinator

Christian Mirian, Medical Doctor, PhD Student

Supervisor / Partners

René Mathiasen, Consultant, Clinical lector and PhD, Maria Thastrup, Post.doc, M.Sc. and PhD, MAtilda Degn Vinther, M.Sc. and PhD, Ole Østergaard. Cand.polyt, and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology, and Jesper Olsen, Consultant

Where

Bonkolab, Neurosurgery Clinic, Centre for Protein Research, Novo Nordisk Foundation, University of Copenhagen

New medicine for children with cancer

Conduct trials of medicines for children and adolescents with cancer, with a special focus on diseases with no standard curative treatment.

Coordinator

Karsten Nysom, Consultant and PhD

Supervisor / Partners

Ruta Tuckuviene, Consultant and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology, and Henrik Hasle, Consultant, Clinical lector and PhD

Where

Rigshospitalet, Department of Paediatrics, section 5002

Contact information

karsten.nysom@regionh.dk

Automated mapping of CNS tumours in children

Automatic mapping of CNS tumours using artificial intelligence trained with expert mapping will ease the workload for doctors and standardise the mapping process for the benefit of patients.

Coordinator

Claes Nøhr Ladefoged, M.Sc. PhD

Supervisor / Partners

Flemming Littrup Andersen, M.Sc. and PhD, Lise Borgwardt, Consultant and PhD, Lisbeth Marner, Consultant, Clinical lector and PhD, Ian Law, Clinical professor and PhD

Where

Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet

Identifying prognostic biomarkers in CNS tumours in children.

Artificial intelligence for decision support in paediatric cancer patients by investigating the correlation between multi-parametric MRI and PET and diagnosis.

Coordinator

Claes Nøhr Ladefoged, M.Sc. og PhD

Supervisor / Partners

Flemming Littrup Andersen, M.Sc. and PhD, Lise Borgwardt, Consultant and PhD, Lisbeth Marner, Consultant, Clinical lector and PhD, Ian Law, Clinical professor and PhD

Where

Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet

Ultra-low-dose PET studies of children

The project will use artificial intelligence to post-process PET scans taken at ultra-low dose, as these are very noisy. A lower radiation dose will minimise the risk of the scan to the child.

Coordinator

Michelle Fridlund, M.Sc. og PhD studerende

Supervisor / Partners

Claes Nøhr Ladefoged, M.Sc. og PhD

Where

Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet

Surgical morbidity in children with brain tumours: A study on postoperative complications of tumour resection

Coordinator

Kasper Amund Henriksen, Medical Doctor and Teaching assistant

Supervisor / Partners

Jon Foss-Skiftesvik, Medical Doctor and PhD, René Mathiasen, Consultant, Clinical lector and PhD, Jane Skjøth-Rasmussen, Consultant, Clinical lector and PhD, and Gorm Von Oettingen, Chief consultant and PhD

Where

National

Contact information

jon.foss-skiftesvik@regionh.dk

Optimal treatment of hydrocephalus in children with posterior fossa tumours: external drain or endoscopic intervention?

Coordinator

Kasper Amund Henriksen, Medical Doctor and Teaching assistant

Supervisor / Partners

Jon Foss-Skiftesvik, Medical Doctor and PhD, René Mathiasen, Consultant, Clinical lector and PhD, Jane Skjøth-Rasmussen, Consultant, Clinical lector and PhD, and Gorm Von Oettingen, Chief consultant and PhD

Where

National

Contact information

jon.foss-skiftesvik@regionh.dk

PET without CT for radiation dose reduction in paediatric examinations

The project will derive a synthetic CT image from the PET scan using artificial intelligence, eliminating the radiation dose associated with acquiring CT images.

Coordinator

Maria Montgomery, B.Sc. student

Supervisor / Partners

Claes Nøhr Ladefogedm M.Sc. and PhD, Flemming Littrup Andersen, M.Sc. and PhD, and Sune Darkner, Professor

Where

Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet and Department of Computer Science, University of Copenhagen

Functional methods for evaluating vision in children with tumors of the central nervous system

Prospective clinical study that aims to investigate visual field and eye movements in healthy children and children with newly diagnosed CNS tumor using a new method called SONDA.

Coordinator

Anna Bøthun, Medical Doctor, PhD student

Supervisor / Partners

Miriam Kolko, Consultant and Professor, Sarah Linea von Holstein, Consultant, Clinical lector and PhD, René Mathiasen, Consultant, Clinical lector and PhD, and Barbara Nordhjem, Post.doc. and PhD

Where

Eye Clinic Rigshospitalet-Glostrup

Contact information

anna.oline.boethun@regionh.dk

Protein, sugar, and fat burning in children and adolescents with CNS-tumors before and after treatment

The project aims to describe the changes that happens in the metabolism more specific the metabolic conversion of protein, sugar, and fat in the approx. two-year long treatment period, that the children go through. This will contribute to a better understanding of the illness and promote the development of new treatments, that prevent malnutrition, loss of muscle mass and lifestyle diseases. The project includes children and adolescents within the age range of 2-21 years who is either newly diagnosed with a brain tumor or done with their treatment for a brain tumor within the last month.

Coordinator

Mette Cathrine Ørngreen, Medical Doctor, dr. Med.

Supervisor / Partners

René Mathiasen, Consultant, Clinical lector and PhD, Alfred Peter Born, Consultant and PhD, Christina Engel Høi-Hansen, Clinical Professor, Thomas Krag, Laboratory chief, Maja Risager Nielsen,MD, John Vissing, Consultant, Clinical lector and PhD, and Gerrit Van Hall, Professor

Where

Rigshospitalet, Copenhagen Neuromuscular center, section 8077 and The Department of Pediatric Oncology section 5054

Detection of circulating tumour DNA for advanced diagnostics and treatment monitoring in children with CNS tumours

The project investigates whether detection of circulating tumour DNA in cerebrospinal fluid in children with CNS tumours can be used for diagnostics, treatment monitoring and assessment of treatment effect.

Coordinator

Ronja Tügel Carstensen, MD, PhD student

Supervisor / Partners

Torben Stamm Mikkelsen, Doctor, Lector, and PhD, LArs Dyrskjøt, Professor, M.Sc. and PhD, Katja von Hoff, Consultant and Clinical Professor, and Britt Elmedal Lauresen, Consultant, Lector and PhD

Where

Children and Adolescents Aarhus University Hospital, Department of Molecular Medicine (MOMA) Aarhus University Hospital

Contact information

ronja.carstensen@clin.au.dk

Thrombocyte RNA for diagnosis and monitoring of brain tumours in children

Trombocytter akkumulerer RNA fra tumorer. Det er vist hos voksne, at man ved kortlægning af mRNA indhold i trombocytter kan kortlægge specifikke genekspressionsprofiler og også identificerer visse af tumorers genetiske forandringer. Metoden har således potentiale til i nogen situationer at overflødiggøre tumorbiopsiere, idet man kan få den molekyler genetiske diagnose fra en blodprøve.

For børn med CNS tumorer vil vi kortlægge mRNA profiler i trombocytter, med henblik på at anvende det diagnostisk.

Coordinator

Supervisor / Partners

Mimi Kjærsgaard, Medical Doctor and PhD, Jonathan Kjær Grønbæk, Medical Doctor and PhD, Maria Rossing, Consultant, Clinical research lector and PhD, René Mathiasen, Consultant, Clinical lector and PhD, and The department of child surgery

Where

Department of Paediatric Oncology and Genomic Medicine

Contact information

mimi.kjaersgaard@regionh.dk

Headache in children and adolescences with brain tumors

Examination of frequency, characteristics, and prognosis of headache in children and adolescences with brain tumors, alongside with the headache’s relation to calcitonin gene-related peptide (CGRP).

Coordinator

Kaja Andersen, PhD student

Supervisor / Partners

René Mathiasen, Consultant, Clinical lector and PhD, and Nanette Mol Debes, Medical Doctor, Clinical research lector and PhD

Where

Bonkolab, Department for children and adolescents at Rigshospitalet, Clinic 3, Herlev Hospital.

Growth hormone deficiency as a late effect of childhood brain tumour

A study of growth hormone deficiency as a late effect of treatment for childhood brain tumours.

Coordinator

Mette Marie Baunsgaard, Medical Student, Scholar

Supervisor / Partners

Anne Sophie Lind Helligsø, Medical Doctor and PhD, Niels Birkebæk, Consultant and PhD, Henrik Hasle, Consultant, Clinical lector and PhD, Torben Stamm Mikkelsen, Medical Doctor, lector and PhD, and Lousie Tram Henriksen, Medical Doctor and PhD

Where

Children and Youth Research, Aarhus University Hospital

Contact information

metbau@rm.dk

Molecular subtyping of pediatric brain tumors using proteomics and phosphoproteomics

This project uses proteomics and phosphoproteomics to molecularly subtype pediatric brain tumors and map their proteomic and signaling landscapes, identifying key pathways driving tumor progression and dysregulated kinase activity. This comprehensive molecular overview will help generate hypotheses for potential therapeutic strategies.

Coordinator

Claire Koenig, Post.doc.

Supervisor / Partners

René Mathiasen, Consultant, Clinical lector and PhD, and Jesper V. Olsen, Professor

Where

Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen

Contact information

claire.koenig@cpr.ku.dk

Ophthalmological manifestations in children <1 year diagnosed with a CNS tumour

The aim is to investigate the ophthalmological manifestations in infants diagnosed with a CNS tumor within the first year of life in order to reduce the time from first symptom to diagnosis.

Coordinator

Nathali Turanzas Jensen, Stud. Med, Scholar

Supervisor / Partners

Sarah Linea Von Holstein, Consultant, Clinical lector and PhD, Rene Mathiasen, Consultant, Clinical lector and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology

Where

Bonkolab and Eye Clinic Rigshospitalet-Glostrup

Nystagmus as a first symptom in children with primary brain tumours

The aim of the study is to investigate the diagnostic and prognostic significance of nystagmus as a symptom and/or clinical finding in children under 18 years of age diagnosed with brain tumours.

Coordinator

Jacqueline Gremaud Rosenberg, Medical Student, Scholar

Supervisor / Partners

Sarah Linea Von Holstein, Consultant, Clinical lector and PhD, Rene Mathiasen, Consultant, Clinical lector and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology

Where

Bonkolab and Eye Clinic Rigshospitalet-Glostrup

Early eye symptoms in children with brain tumours

Retrospective study of early eye symptoms in children with brain tumours in the time leading up to diagnosis with the aim of earlier diagnosis

Coordinator

Jacob Christiansen, Medical Student, Scholar

Supervisor / Partners

Sarah Linea Von Holstein, Consultant, Clinical lector and PhD, Rene Mathiasen, Consultant, Clinical lector and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology

Where

Bonkolab and Eye Clinic Rigshospitalet-Glostrup

Visual impairment in children with primary brain tumours

The aim of the study is to investigate the diagnostic and prognostic significance of visual impairment as a symptom and/or clinical finding among paediatric patients diagnosed with brain tumours.

Coordinator

Caroline Sophie Kleis Schmidt, Medical Student, Scholar

Supervisor / Partners

Sarah Linea Von Holstein, Consultant, Clinical lector and PhD, Rene Mathiasen, Consultant, Clinical lector and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology

Where

Bonkolab and Eye Clinic Rigshospitalet-Glostrup

Afsluttede forskningsprojekter

Genetic predisposition to the development of CNS tumors

The study seeks to investigate genetic predisposition for the development of CNS tumors in childhood through the use of a retrospective Danish cohort.

Coordinator

Jon Foss-Skiftesvik, 1st reserve doctor in neurosurgery, PhD student

Supervisor / Partners

Jonas Bybjerg-Grauholm, M.Sc., René Mathiasen, Consultant, Clinical lector and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology, and Marianne Juhler, Consultant and Professor in neurosurgery

Where

Department of Congenital Diseases and Neonatal Genetics, Statens Serum Institut; Bonkolab Neurosurgery Clinic

Contact information

jon.foss-skiftesvik@regionh.dk

Late effects after childhood brain tumour treatment

Coordinator

Anne Sophie Lind Helligsø, Medical Doctor, PhD Student

Supervisor / Partners

Jeanette Falck Winther, Consultant and Professor, Henrik Hasle, Consultant, Clinical Professor and PhD, Louise Tram Henriksen, Medical Doctor and PhD, and Line Kenborg, M.Sc. and PhD

Where

Aarhus University - Aarhus University Hospital

Contact information

aslf@dadlnet.dk

Biomarkers in pediatric chemotherapy-induced peripheral neuropathy

A clinical study investigating the potential for a reliable biomarker to assess both the risk of development and the severity of chemotherapy-induced peripheral neuropathy. A task that, with current methods, is both difficult and resource intensive.

Coordinator

Christian Bach Vase, Stud. Med., former scholar, Peter Erik Lotko Pontoppidan, Department physician, PhD, Rigshospitalet

Supervisor / Partners

René Mathiasen, Consultant, Clinical lecturer and PhD, and Tore B. Stage, Professor, PhD, Cand.pharm,

Where

Bonkolab, Department of Health Services Research, University of Southern Denmark

Establishment of cell lines and mouse models (patient-derived xenografts) from childhood brain tumors

Establishment of mouse models for the purpose of pre-clinical testing of drugs, among other things.

Coordinator

Henriette Pedersen, biomedical scientist, PhD student

Supervisor / Partners

René Mathiasen, Consultant, Clinical lecturer and PhD, Petra Hamerik, Professor and PhD, Kjeld Schmiegelow, Professor in pediatrics and pediatric oncology, and Marja Jäättelä, Professor and PhD

Where

The Danish Cancer Society, The Brain Tumor Biology Group

Contact information

henped@cancer.dk

Characterisation of the innate metabolome in children with CNS tumours

Projektet søger at afklare om det medfødte metabolom i perifert blod hos børn som udvikler CNS-tumorer adskiller sig fra det i raske kontrolpersoner, og i hvilken grad det i givent tilfælde kan benyttes som screeningsmetode eller prognostisk markør.

Coordinator

Jon Foss-Skiftresvik, 1st resident in neurosurgery, PhD Student

Supervisor / Partners

Madeleine Ernst, M.Sc. and PhD, and René Mathiasen, Consultant, Clinical lecturer and PhD

Where

Department of Congenital Diseases, Statens Serum Institut; Bonkolab, Neurosurgery Clinic,

Contact information

jon.foss-skiftesvik@regionh.dk

Melatonin secretion during puberty – A systematic review

As part of the project "Sleep hormones in healthy children - reference material for the treatment of sleep disorders in children with CNS tumours", a systematic review on melatonin concentrations in children and adolescents has been written.

Coordinator

Christian Corfitz Andersen, Medical Student, Scholar

Supervisor / Partners

Rene Mathiasen, Consultant, Clinical lecturer and PhD, Poul Jørgen Jennum, Consultant and Professor in clinical neurophysiology, and Nanette Marinette Monique Debes, Medical Doctor, Clinical researcher and PhD

Where

Bonkolab, Danish Centre for Sleep Medicine, Neurophysiology Clinic

Regulatory mechanisms in Diffuse Infiltrating Pons Gliomas (DIPG)

Research field: In Vitro models (cell cultures), RNA regulation in DIPG, epigenetic regulation, screening models for drugs. Pilot studies for the establishment of Patient derived xenograft (mouse models).

Status:
1) Functional analysis of DNA damage signalling pathways and selected DNA repair pathway in paediatric H3K27M mutant and H3K27 wild-type gliomas has been performed. Further investigation of the activation of DDR with and without ionising radiation needs to be included as well as a microscopy-based quantification of foci formation to see the broader picture.

2)
A drug screening using the CNS-permeable drug library for radiosensitivity of H3K27M-mutated paediatric gliomas has been performed. This objective was split into two sub-objectives A (CNS drug screen) and B (drug validation and in vivo assessment). This has been finalised.

Coordinator

Henriette Peder, Biomedical scientist, PhD student

Supervisor / Partners

René Mathiasen, Consultant, clinical lecturer and PhD

Where

Denmark

Contact information

henped@cancer.dk

The diagnostic value of 18F-FET PET/MR in CNS tumors in children and adolescents

The project seeks to clarify the diagnostic value of 18F-FET PET/MR in CNS tumours in children and adolescents, including the modality's ability to differentiate residual tumor compared to MRI.

Coordinator

Lisbeth Marner, MD, PhD, Clinic for Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet

Supervisor / Partners

Astrid Sehested, Consultant, Karsten Nysom, Consultant and PhD, Helle Broholm, Consultant, and others

Where

Clinic for Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet

Contact information

lisbeth.marner@regionh.dk

Infection risk associated with the need for liquor drainage in children with CNS tumours

The risk of infection in paediatric patients with intracranial tumours and external ventricular drainage or ventriculoperitoneal shunt.

Coordinator

Anna Bøthun, Medical Student, Scholar

Supervisor / Partners

René Mathiasen, Consultant, Clinical lecturer and PhD, Jane Skjøth-Rasmussen, Consultant, Clinical lecturer and PhD, Madja Hawwa Vissing, Chief Consultant, Clinical lector and PhD, and Jon Foss-Skiftesvik, Medical Doctor and PhD

Where

Rigshospitalet

Contact information

anna.oline.boethun@regionh.dk

Sleep disorders in children with CNS tumours

Sleep disorders in children treated for brain tumours (neurobiological markers of sleep disorders)

Coordinator

Line Pickering, Doctor, PhD student

Supervisor / Partners

Where

Contact information

Neuropsychological testing in children with CNS tumours

Neuropsychological testing of children who have had a brain tumour, as well as psychological counselling for children and relatives. Is this done to a sufficient extent.

Coordinator

Clara Emilie Bruun, Medical Student, Scholar

Supervisor / Partners

René Mathiasen, Consultant, Clinical lecturer and PhD, and Jonathan Grønkjær

Where

Rigshospitalet

Contact information

clara.emilie.bruun@regionh.dk

Evaluation of MRI surveillance of children with brain tumours

Follow-up regimens for brain tumours and their value. Early identification of recurrence of brain tumours.
af hjernetumorer

Coordinator

Christoffer Storm Svendsen, Medical Student, Scholar

Supervisor / Partners

René Mathiasen, Consultant, Clinical lecturer and PhD, Astrid Marie Sehested, Consultant, and Jonathan Grønkjær

Where

Rigshospitalet

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